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However, a key unresolved question is how the specificity, reversibility, and spatiotemporal dynamics of SSG are coordinated across different cellular compartments and pathological contexts

In particular, during the acute phase, in which HCV replicates at a high rate, a marked oxidative stress due to the NOX4 isoform, ubiquitously expressed in parenchymal and non-parenchymal liver cells, has been observed, as well as a concomitant decrease in GSH

Zhang H, Wang Y, Wang S, et al

Tongbin Chen, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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