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Youth nicotine or tobacco use in any form, whether smoked, smokeless "vaped" (e-cigarettes or "vaping"), is not safe

[7] Thomas Brown, An Exhortatory Letter, to an Old Lady that smoakd Tobacco in The Compleat Works of Thomas Brown, in Prose and Verse

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[16] Nicotine deregulates cardiac autonomic function, boosts sympathetic activation, raises heart rate, causes coronary and peripheral vasoconstriction, increases myocardial workload, and stimulates adrenal and neuronal catecholamine release

Thus I conclude that for countries with pyramidal demographics, e.g