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Furthermore, ZLN005 treatment activates mitophagy, as manifested by increased expression of LC3-II and co-localization between LC3 and mitochondria, and the protective effects are abrogated in TFEB-knockdown cells, suggesting that PGC-1 activation improves mitochondrial dysfunction via TFEB-mediated autophagy

doi:10.1093/qjmed/95.9.609

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Alternative Therapies in Health and Medicine , 12(4), 1223