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A similar nicotine regimen also decreases body weight and fat mass in mice as a result of 4* nAChR-mediated activation of POMC neurons and subsequent activation of MC4 receptors on second order neurons in the paraventricular nucleus of the hypothalamus (Mineur et al., 2011)

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The genetic events hint on the possible use of genomicepigenomic changes in genes related to cancer, in predicting cancer risks associated with exposure to tobacco smoking