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population PK modeling of the DM4-based ADC, tusamitamab ravtansine (DAR ~ 3.8), characterized the irreversible deconjugation from higher to lower DAR species as a key determinant of its overall disposition [51]

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(2) Antiinflammation: inhibition of inflammatory mediators (e.g., NSAIDs) or selective targeting of COX2 via prodrugs is depicted to attenuate inflammationdriven oxidative stress

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