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Beta-blockers: These medicines can reduce HDL or healthy cholesterol levels and raise the level of triglycerides, a fatty acid tested for in cholesterol tests

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At this time, the physical pulling of the skin causes the canonical mechanotransduction (YAP) signal to activate Engrailed-1, which promotes an EPF-mediated fibrotic response instead of the normal ENF-mediated wound regeneration response, creating fibrotic scars