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This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

With a healthy nervous system, over-production of the stress hormone that causes the fight or flight response (cortisol) can be prevented

By blocking NNMT, 5-Amino-1MQ restores NAD+ availability in fat cells, shifting their behavior toward fat mobilization and oxidation rather than storage