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The key to the integrity of this barrier is moisture, specifically keeping water inside the skin

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They may also develop oral cancer

Heavy smokers were defined as those who smoked more than one pack of cigarettes daily

In truth, the negius of an addiction is so profound that it causes one to wonder if such an addict should be the one deciding if his addiction of choice is halachically acceptable (see, however, the amazing words of the Chazon Ish in Emunah UBitachon 3:30quoted in Shaarei Aharon to Devarim 16:19where he explains that often halachah does indeed allow one who has something to gain or lose from a psak to be the arbiter)