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[12] Tobacco-specific impurities such as cotinine, nicotine-N'-oxides ( cis and trans isomers), and beta-nornicotyrine are believed to be the result of bacterial action or oxidation during the extracting of nicotine from tobacco

10643, otherwise known as the Graphic Health Warnings Law, GHWs are photographic images printed on the tobacco product package which accurately depict the hazards of tobacco use and are accompanied by textual warning related to the picture (5). Signed in 2014 and implemented in 2016, the law introduced current GHWs on tobacco products, changing designs every 2 years (5)