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Due to low salivation, there is ample chance of acid damage due to refluxed acid Acid secretion in the stomach - Smoking intensifies the stomach acid and triggers excessive production of the acid in the stomach

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While this is in some ways a cultural effect, as smoking is much more widely accepted, the lack of access to tools like vaping could play a big part in smoking rates being as high as they are

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Thus, we used the methylated genes from blood samples more extensively for pathway-based analysis and used the methylated genes from buccal samples only for replication