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bioRxiv, 2020

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While alcohols effect on nicotine receptors in the brain has been thoroughly researched, the receptors interaction with coffee has been studied less

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Tobacco and cannabis use in isolation have devastating consequences for people with psychosis, so we wanted to see if people who co-use cannabis and tobacco had more severe psychiatric symptoms and if they were at greater risk for developing psychosis in the first place. The study found that regular use of either cannabis or tobacco was linked to anxiety, depression and early psychotic experiences