making smokeless tobacco How to Make Chewing at Home with Whole Leaf Tobacco Cigarettes, Smokeless Tobacco, and Vapes:

"This change in flow as seen on a brain scan correlated with changes in how the smokers themselves reported feeling before and after smoking." The orange dots on these brain scans show the areas where the biggest changes in opioid activity took place after smokers began smoking a regular cigarette

As a reactive a,b-unsaturated aldehyde, acrolein can exacerbate dyslipidemia that can lead to accelerated atherosclerosis, modify A-I protein in high-density lipoprotein (HDL) [33, 34] and catalytic neutrophil-mediated inflammation [35], and enhance platelet activation which contributes to an increased risk of thrombosis in animal models [36]

After smoking, cold-smoked meats must be fully cured and cooked before eating

N Engl J Med 382, 697705

So while the numbers of smokers are high somewhere between 650,000 and 900,000, depending on the source so, too, are the health risks