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Although the insulas role in interoceptive monitoring has been well characterized [80] and higher nAChR availability in the thalamus, PFC, and cerebellum has been positively correlated with increased pain sensitivity among abstinent smokers [96], relatively little neuroimaging work has focused on the neurobiological processes that may contribute to smoking- or withdrawal-related pain dysregulation

That'd tie up the plot in a nice little bow, but it wouldn't make much sense

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As the voice for Canadians who care about cancer, we work with governments to establish health policies to prevent cancer and better support those living with the disease

This makes it hard for patients to come off them