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103 Another possibility involves TLR2, which, when engaged on DCs, can result in the induction of Th2 responses in the lung

The tobacco industry is also very strategic at avoiding taxes by forestalling/front-loading sales right before tax increase, raising prices in anticipation of tax (so it looks like the tax was ineffective), offering discounts to price-sensitive customers, moving into low-price options, and lobbying for their preferred form of taxation (WHO 2021 tax manual page 43)

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Looking around for best practices works in government as well as business

Duty rates alone dont represent the full landed cost