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Other lifestyle factors, for example, use of alcohol or other drugs, also make a difference in long-term outcomes for smokers

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If you are comparing open heart surgery with a drug treatment, then you cannot blind the doctor or the patientboth the physicians and patients will know who is undergoing open heart surgery and who is not.[258] Optimal experimental practice, however, entails randomized, controlled, double-blinded studies to the extent possible for a given situation