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Considering the specific safety concerns, contraindications (for example, bupropion is contraindicated in patients who have seizures) and comorbidities, the choice of agent is based largely on patient preference after discussion with a clinician [footnote 53]

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9, National Institutes of Health, Bethesda, pp 161179 Savdie J, Canha N, Buitrago N, Almeida SM (2020) Passive exposure to pollutants from a new generation of cigarettes in real life scenarios

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This has led to stricter regulatory measures, such as age verification and flavor restrictions, designed to curb usage among minors