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Hepatotoxicity Apremilast is generally recognized for its favorable hepatic safety profile, particularly compared to systemic therapies like methotrexate and acitretin

However, In Colombia only some determinations have taken place in small groups (data without publishing), and there exist small work groups from certain universities like the Universidad del Rosario of Bogotas, who will soon give their results in relation to the prevalence of this alteration in the metabolism of hereditary type

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In addition, we used cubic restricted splines (with knots at 10, 50, and 90% percentiles) on IGF-1 as continuous variable to model a possible nonlinear association with mortality

Pregnant or nursing mothers, children under 18, or individu- als with known medical conditions should consult a physician before use