can tobacco cause psychosis Does use psychosis? Systematic review and meta-analysis Schizophrenia and Smoking

Mol Psychiatry (2014) 19:20

Nicotine also binds 42, a high-affinity receptor along GABA neurons, which, with chronic nicotine use, become desensitized, therefore dampening the inhibition on dopaminergic transmission from the VTA to the NAc, while 7, low-affinity nAChRs on glutamatergic neurons are less prone to desensitization, therefore continue to enhance dopamine transmission (94, 95)

This last point is particularly important in the content of ongoing debate regarding the potential harms and benefits of electronic cigarettes

Donnini's primary practice is multi-state sales and use tax as well as state corporate income tax controversy

Hot on the heels of a recent study suggesting a dose-response relationship between tobacco smoking and subsequent risk of psychosis, a systematic review and meta-analysis (including the data from that prospective study) has now been published, again suggesting that we should be considering the possibility that smoking is a causal risk factor for schizophrenia