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Inhaled cigarette smoke first encounters the airway epithelium, where it may induce oxidative stress by both acute effects of its reactive components and by the intracellular generation of endogenous reactive oxygen species (ROS) by mitochondria [16]

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This was realized with convincing results by the replacement of a suitably exposed serine by a cysteine residue, which then was equipped with its analogue Sec through heterologous expression in a bacterial system auxotrophic in cysteine (Figure 7)

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A person who is poisoned with EG may appear drunk