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[168] have demonstrated that over-expression of hMTH1 significantly attenuates the mutation rates in DNA mismatch repair (MMR) defective mouse- and human cells, suggesting that the high spontaneous mutation rates in MMR-defective cells are mostly due to incorporation of oxidized dNTPs into DNA, and less likely, caused by spontaneous replication errors

Nowrin K, Sohal SS, Peterson G, et al

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This not only adds a subtle accent to the design but also provides friction to prevent slipping when igniting