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No obvious toxicity has been reported in rodent studies at effective doses

In turn, enhancing KCC2 activity not only potentiated L838,417-induced analgesia, it rescued its analgesic potential at high doses, revealing a novel strategy for analgesia in pathological pain, by combined targeting of the appropriate GABA A R-subtypes and restoring Cl - homeostasis

[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Castro-Marrero J., Domingo J.C., Cordobilla B., Ferrer R., Giralt M., Sanmartin-Sentanes R., Alegre-Martin J

(2018) found that GHK modulated the expression of over 4,000 human genes