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Lastly, we showed that optogenetic stimulation of astrocytes during hypoxia induced released of lactate and was correlated with neuroprotection, as demonstrated by the preservation of both spontaneous electrophysiological activity and cell viability

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Glutamine plays a crucial role in the glutaminolysis pathway, where it is converted into glutamate and -ketoglutarate, intermediates in the tricarboxylic acid (TCA) cycle [48]