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these were unable to recover muscle-to-bone attachment to any extent

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It will often not happen on the first GSH (it can of course) but if there are methyl cycle slow downs and then yOu supply the B Vit cofactors and a methyl donor suddenly the methyl cycle donates more and more to the HCYS-Cystathionine pathway (which primes sulfite formation and SUOX) and THEN you give GSH which also donates to the same pathway A sulfite reaction can look like anaphylaxis and can have hive reactions and all you mention

A consistent rhythm of three to four sessions per week is often more beneficial than pushing for marathon sweats

Lack of UGT1A1 activity is often associated with another problem since UGT1A1 activity usually decreases to 1035% from normal and bile pigments show a distinctive rise in bilirubin monoglucuronides