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Ling ZN, Jiang YF, Ru JN, Lu JH, Ding B, Wu J

1992 and citations therein)

In contrast, neurons prioritize maintaining ion gradients for electrical signaling, with mitochondria concentrated near synapses to support neurotransmitter release

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Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)