Unlike exogenous human growth hormone (HGH) replacement, which can shut down natural production, secretagogues work by signaling the pituitary gland to release its own stored GH
doi: 10.1093/hmg/ddn184 494 HirschfieldGMLiuXXuCLuYXieGLuYet al
Have There Been Human Trials
the resulting fall in the leptin/adiponectin ratio relieves STAT3, MAPK, and PI3K signaling while activating AMPK and dampening mTORC1 372,373,374,375
doi: 10.3389/fphar.2021.724439 Received 13 June 2021 Accepted 14 December 2021 Published 24 January 2022 Volume 12 - 2021 Edited by Ashwell Rungano Ndhlala, University of Limpopo, South Africa Reviewed by Muhammad Nadeem, University of Veterinary and Animal Sciences, Pakistan Bin Zeng, South China Agricultural University, China Updates Copyright 2022 Alia, Putri, Anggraeni and Syamsunarno