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A relationship between elevated blood pressure and vascular oxidative stress was also shown in patients with essential, 5, 6 renovascular 7 or malignant hypertension

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In a preferred embodiment, the process of the invention uses special equipment for crystallisation, as it has been observed that particular stirrers with low shear strength give rise to rapid, complete dissolution of the product in amorphous form and better reproducibility of precipitation, especially when the alpha crystalline form is to be obtained