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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin
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This comprehensive analysis examines the chemical structures, stability profiles, and interaction potential of each peptide to determine whether the combination is chemically defensible
Interestingly, we found that -syn knockout mice or siP-Syn mice were resistant to a chronic hypoxia-induced decline in PP2A activity, showing no increase in the p-PP2A/PP2A ratio after hypoxia (Fig
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