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doi:10.1212/CPJ.0000000000000043 In addition, there are several limitations in the research that has been conducted, such as: Many studies do not include the use of fluoroscopy or x-ray to verify the proper placement of the medication despite the fact that fluoroscopic guidance is routinely used today

Testing must therefore characterize both the formulation (assay, purity, pH, osmolality, viscosity, microbial safety) and the device performance (spray pattern, plume geometry, droplet size distribution, dose uniformity, priming behavior) as an integrated system

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