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Current programs include more comprehensive testing of qualified athletes and random testing of competitors at the Games

Abbreviations ABTS: 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) AG490: JAK2 Inhibitor AKT: Protein Kinase B AML: Acute Myeloid Leukemia AMPK: AMP-activated protein kinase AP-1: Activator Protein 1 AR: Androgen Receptor ATP: Adenosine Triphosphate Bax: Bcl-2-associated X protein Bcl2: B-cell lymphoma 2 BIR: Baculoviral IAP Repeat CDK: Cyclin-Dependent Kinase CHOP: C/EBP Homologous Protein CML: Chronic Myeloid Leukemia CYP: Cytochrome P450 DPPH: 1,1-diphenyl-2-picrylhydrazyl DNA: Deoxyribonucleic Acid EMT: Epithelial-Mesenchymal Transition EPR: Enhanced Permeability and Retention ER: Endoplasmic Reticulum Fas: Fas Cell Surface Death Receptor GC: Gas Chromatography HCT-116: Human Colon Cancer Cell Line HER-2: Human Epidermal Growth Factor Receptor 2 HIF-1: Hypoxia Inducible Factor 1 HOS: Human Osteosarcoma Cell Line HPLC: High-Performance Liquid Chromatography HSC3: Human Squamous Cell Carcinoma Cell Line Hsp70: Heat Shock Protein 70 Hsp90: Heat Shock Protein 90 IL-1: Interleukin 1 beta JAK: Janus Kinase JNK: c-Jun N-terminal Kinase LPS: Lipopolysaccharide MAPK: Mitogen-Activated Protein Kinase MCF-7: Human Breast Cancer Cell Line MDA-MB-231: Human Breast Cancer Cell Line MDM-2: Mouse Double Minute 2 homolog MMP: Matrix Metalloproteinase MS: Mass Spectrometry NAD + : Nicotinamide Adenine Dinucleotide NCOR2: Nuclear Receptor Corepressor 2 NF-B: Nuclear Factor kappa-light-chain-enhancer of activated B cells NMR: Nuclear Magnetic Resonance NQO1: NAD(P)H Quinone Accepting Oxidoreductase 1 PARP: Poly(ADP-ribose) Polymerase PC-3: Prostate Cancer Cell Line PEG: Polyethylene Glycol PI3K: Phosphoinositide 3-Kinase Pin1: Peptidyl-prolyl cis/trans isomerase PLC: Phospholipase C PTX: Paclitaxel RAW264.7: Murine macrophage cell line ROS: Reactive Oxygen Species S6K: Ribosomal Protein S6 Kinase STAT3: Signal Transducer and Activator of Transcription 3 TLC: Thin-Layer Chromatography TNF-: Tumor Necrosis Factor alpha UAE: Ultrasound-Assisted Extraction VEGFA: Vascular Endothelial Growth Factor A WHO: World Health Organization XIAP: X-linked Inhibitor of Apoptosis Protein References Bolton JL, Trush MA, Penning TM et al (2000) Role of quinones in toxicology

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IFN- produced by mucosa-associated invariant T (MAIT) cells was reduced in the peripheral blood and liver of HCC patients than in the controls (Huang et al., 2021)