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FIGURE 10 Oxidative stress, associated with high dose MTX, triggers a systemic inflammatory response where proinflammatory cytokines further contribute to tissue damage ( During stressful conditions, such as MTX-induced oxidative damage, unresolved ER stress leads to the accumulation of unfolded proteins promoting apoptosis (Figure 1)

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Here, the sharp decline in glutathione (GSH) levels, especially in the liver, to almost zero is effectively counteracted by NAC [10]

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Gene score calculation of risk genes Using UCell 36 via AddModuleScore_UCell, we obtained cell-level scores for autism-specific gene lists (inflammation-related gene sets) and quantified the pre/post L-serine score for each signature

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Glutathione injections vs

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