Early kinetic analyses suggested that sulfite is a preferred sulfur acceptor in this reaction, as it exhibits a high k cat / K m (2.9 10 7 M -1 s -1 ) ( K m value (200 M), it is now considered that the physiologically most relevant sulfur acceptor is GSH
Lipid peroxidation generates hydroperoxides as well as endoperoxides, which undergo fragmentation to produce a broad range of reactive intermediates called reactive carbonyl species (RCS) such as isoprostanes (IsoPs), neuroprotanes, malondialdehyde, unsaturated aldehydes including 4-hydroxy-2- trans -nonenal (HNE), 4-hydroxy-2- trans -hexenal (HHE), and 2-propenal (acrolein), with different degrees of reactivity (Porter et al., Clearly, the concurrency of these factors in the presence of high amounts of polyunsaturated fatty acids, mainly DHA, is expected to favor the free radical-induced peroxidation of DHA in the brain parenchyma (Van Kuijk et al., Nerve cells are endowed with different antioxidant systems that render them protected from oxidative damage caused by lipid peroxides
Feng, J
In laboratory research, it is widely studied for its involvement in peptide-regulated signaling, cytoprotective mechanisms, and cellular communication pathways associated with tissue modeling and biological adaptation
Delta sleep inducing peptide inhibits somatostatin release via a dopaminergic mechanism
