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Progress in vesicular formulations, including ultra-deformable liposomes (transfersomes and ethosomes), has enhanced skin permeability by allowing the vesicles to go across intercellular routes in the stratum corneum under osmotic gradients or ethanol-induced lipid fluidisation [258, 281]

The truth of the matter is that the permeability pathways of many of the probes are still unclear

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The Polygonum cuspidatum extract markedly suppressed the production of COX-2, IL-6, and TNF-, as well as the activation of NF-B p65 in hyperosmolar stress-induced HCECs