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A serendipitous outcome to the preclinical studies with TLK199 was the observation that TLK199 behaves as a small molecular myeloproliferative agent in rodents (Ruscoe et al ., 2001)

189 During the maturation of RPE, PGC-1 increases the expression of antioxidant genes, including catalase (CAT), glutathione peroxidase (GPX)1, peroxiredoxin (PRDX) 3, SOD1, SOD2, and TXN2, and represses oxidant-mediated cell death in RPE

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It is being tested to treat obesity and type 2 diabetes by itself and in combination with semaglutide as cagrilintide/semaglutide ("CagriSema")

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