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We observed that in the 5mM 5-OP-treated cells the intracellular levels of 5-OP increased 12-fold, while in 10mM it had increased 20-fold (Fig 1D)

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& Shah, Z

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The serum from rats treated with APAP, which causes hepatocellular damage, showed the largest increase in CA, therefore leading the authors to hypothesize that a large increase in CA may be a potential marker for hepatocyte damage

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Mammals mostly use nicotinamide to make NAD

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