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A 2025 narrative review in Current Reviews in Musculoskeletal Medicine identified only three published human studies: Lee & Padgett (2021) on knee pain (n=16), Lee et al

The determination of hydrodynamic diameter and PDI is very difficult in the case of multi-armed polymers, because the non-spherical shape of nanocarriers is one of the limitations of dynamic light scattering measurement technique [57]

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