Additionally, it was found to have anti-pyroptotic potential by suppressing the levels of NLRP3, caspase-1, GSDMD, and IL-1 in the granulosa cells (Biasizzo and Kopitar-Jerala 2020)
Curcumin increases Nrf2 expression and its downstream targets HO-1 and GPX4 in hepatocytes, 452 cardiomyocytes, 504 neurons, 679 renal tubule cells 865 and chondrocytes, 882 protecting against diseases by inhibiting ferroptosis
The efficacy and tolerability of a food supplement based on pomegranate extract, B vitamins, and vitamin C was successfully evaluated against prolonged fatigue in healthy subjects (Esposito et al
10.3233/JAD-170543 12 AmorosoR.MaccalliniC.BellezzaI
These targets may also provide greater sensitivity to subtle or chronic forms of neuroinflammation that are not reliably captured by first- or second-generation TSPO tracers