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Conversely, others and our laboratory have demonstrated that NO can favor GSH synthesis via the NEFL2-mediated transcription of GCL ( The role of GSH as NO scavenger is also highlighted by To investigate the importance of correct GSH homeostasis for the neurotrophic capacity of NO, 2 -Tyr) protein accumulation ( Figure 1 )

Poor lifestyle choices and environmental factors (e.g., pollution) accelerate this decline