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Alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: Understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis

Xuzhou Yi Xue Yuan Xue Bao 28:335337

Researchers are working to create single drugs that incorporate multiple pharmacophores, thereby addressing various aspects of AD, such as cholinergic and amyloidogenic processes, oxidative stress, neuroinflammation, metal chelation, and the inhibition of other enzymes that have significant roles in these neurodegenerative processes (Sampietro et al

Menariknya, hubungan antara bubuk peptida tembaga dan retinoid itu sendiri menghadirkan tantangan formulasi yang memerlukan perencanaan strategis

Potent inhibition of CI by IACS-010759 resulted in neurotoxicity at concentrations required for therapeutic benefit 51