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Following secretion, PYY is rapidly cleaved by dipeptidyl peptidase-4 (DPP-4) to its active form (PYY 3-36) acting on neuropeptide Y receptor type 2 (Y2R)

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Saline contains 0.9% sodium chloride dissolved in water, making it isotonic with the body, while sterile water contains no dissolved salt

The control condition without on-chip BBB (just the PET membrane) showed a significantly higher effect (viability: 58.69 13.07%) upon dosage of 1 M cisplatin, suggesting that the on-chip BBB hindered the permeation or retained cisplatin