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Hadwans research further illustrated that fertile men possessed higher proportions of high-molecular-weight ligands than their infertile counterparts, and treated men with OAT saw an increase in high-molecular-weight ligands and normalization of low-molecular-weight ligands [135]

However, activation of the NF-B pathway in combination with GPX4 knockdown effectively triggered ferroptosis, indicating a synergistic role of NF-B signaling in RSL3-induced ferroptosis [35]