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Availability of data and materials The data set used during the current study are available from the corresponding author on reasonable request

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Closest Analog: Cagrilintide + Semaglutide REDEFINE 1 (Garvey et al., NEJM 2025) is the only Phase 3 trial of an amylin + incretin co-administered combination in adults without diabetes

Reduced activity of RCT, due to diminished levels of PON1, LCAT, and ApoA1, may lead to excessive accumulation of free cholesterol, resulting in the generation of oxysterols that could subsequently activate IRS and induce O&NS