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Murphy E, Steenbergen C (2007) Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury

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32 It was documented that oxidative stress, cholinergic insufficiency, and the accumulation of A and NFTs occurred in the brains of rats following oral administration of aluminium at a dosage of 300 mg/kg body weight

Beyond-use periods must follow the SmPC : Generic claims about multi-dose vials remaining usable for a fixed number of days are not appropriate