The authors proposed that MOTS-c levels could serve as a predictive indicator for aerobic capacity, body-fat status, and endurance training load.14 This raises an intriguing possibility for endurance practitioners: MOTS-c as a blood-based biomarker for mitochondrial fitness, complementing VOmax and lactate threshold in a multi-modal assessment framework
Int J Pept Res Ther 27:22912301 Wang M-D, Hou D-Y, Lv G-T, Li R-X, Hu X-J, Wang Z-J, Zhang N-Y, Yi L, Xu W-H et al (2021b) Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency
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This distinction matters because tissue organization directly determines mechanical function and long-term durability
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12, 470