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Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition

Include vitamin B-rich foods such as whole grains, eggs, dairy products, legumes, nuts, and green leafy vegetables in your diet

These injections, sometimes called a B12 shot, are administered intramuscularly, ensuring immediate absorption and utilization by the body

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NICE does not currently have guidance on either AOD 9604 or retatrutide, reflecting their unlicensed and investigational status within the UK healthcare system