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It has been found that ineffective erythropoiesis in -thalassemia is closely associated with a high accumulation of Reactive oxygen species, a product of oxidative stress, in erythroid cells

A lot of that gets missed on me because I'm speeding through to get to the outcome

(2) SAM's Methyl Donor Function and Methylation Reactions As a universal methyl donor, SAM participates in diverse methylation reactions mediated by methyltransferases, transferring its methyl group to substrates like DNA, RNA, and proteins

Effraimidis G, Wiersinga WM (2014) Mechanisms in endocrinology: autoimmune thyroid disease: old and new players

It helps neutralize free radicals, support detoxification, and keep your cells internal environment in balance