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Potential theoretical concerns include: Unregulated angiogenesis Immune system modulation Tumor growth acceleration under certain conditions Reproductive safety implications Cardiovascular remodeling There is no clinical evidence demonstrating these risks in humans, but comprehensive trials evaluating these endpoints do not exist

Cell fitness over YFP + or nTnG cells was measured by quantifying fold increase of YFP or p53*-TC cells respectively at the specified time point versus its proportion at the initial time point

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