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J Allergy Clin Immunol (2020) 145(1):199214.e11

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Zn II -Sensing MarRs Zn II -sensing MarRs are the only characterized metalloregulatory proteins from this very large superfamily, while also constituting an exception to the rule of allosteric inhibition of DNA binding as a general feature of MarR proteins

Consistent with these studies, a recent study in healthy NS workers demonstrated that moderate alcohol consumption further altered peripheral clock gene amplitude in CLOCK, BMAL1, PER1, CRY1, and CRY2, and it was associated with increased colonic permeability, highlighting the compounding effects of environmental circadian disruption and lifestyle factors on peripheral clock gene regulation 143

K., Chen, J