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Patients with pernicious anemia or others who cannot absorb B from food typically need lifelong B therapy, often on a monthly injection schedule

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Safety and tolerability of the hexadecapeptide AOD9604 in humans. J Endocrinol Metab 3(12):715

Intravenous is usually done under hospital care when patients are in dire need of receiving large doses rapidly

Series 2: 3-AR knock-out mice (the gene for the 3 receptor is knocked out) in the same design, to check whether 3 is necessary for the AOD-9604 effect