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Our identification of the Human-SFB-refML lineage in South America 80,84,89 , including in the indigenous Tsimane horticulturalists of the Amazon in Bolivia, children from the Amazonian lowlands in Peru, and individuals from the Amazonas Guahibo Amerindians in Venezuela, is also intriguing (Supplementary Data 4)

Not great for an entire PO regimen.) The IV protocol is a 20 hour treatment: Loading Dose: 150 mg/kg (max: 15 g) infused over 1 hour Second Dose: 50 mg/kg (max: 5 g) infused over 4 hours Third Dose: 100 mg/kg (max: 10 g) infused over 16 hours The PO protocol is a 72 hour treatment (rotten eggs for 72 hours!!): Loading Dose: 140 mg/kg Maintenance Dose: 70 mg/kg every 4 hours for a total of 18 doses NAC is typically the first-line option for the treatment of acetaminophen toxicity

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Acta 461 , 4146 (2016)