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MOTS-C is a 16-amino acid mitochondrial peptide that activates AMPK, improves insulin sensitivity, and supports fat oxidation

Physicochemical changes appear that prepare the body to cope with the demands

All published evidence comes from rodent models, cell cultures, or ex vivo tissue samples

Several changes in structural (reduced tendon CSA and fibril diameter), cellular (decreased cell proliferation and stem/progenitor cell quantity), and mechanical properties (reduced modulus and strength), beyond just alterations to AGE-mediated crosslinks, occur in tendon during the aging process and have been recently reviewed in detail (Svensson et al ., 2016)

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